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Genome editing used to birth castration-free prototype piglets

Since these prototype pigs were created to be permanently prepubescent, the alliance is determining how to breed these pigs without comprising traits like feed efficiency and meat quality.

Recombinetics/Acceligen and Hendrix Genetics have discovered a successful genome editing method to create swine that remain in a pre-pubertal state, thus eliminating the need for surgical castration. The first litter of castration-free prototype piglets using commercially relevant genetics confirms the methodology is working.

In 2017 the Foundation for Food and Agriculture Research awarded a grant to Recombinetics to end surgical swine castration. Since then, Recombinetics/Acceligen and Hendrix Genetics, pioneering companies in swine genetics, responsible farm animal breeding and precision breeding technologies, formed the “Alliance to End Surgical Castration of Swine.” This venture developed an approach that prevents sexual maturation in swine without introducing any foreign material into the genes of pigs. 

“This first litter of permanently prepubescent piglets is a huge success,” says Sally Rockey, FFAR executive director. “Not only does the industry benefit, but once this technology is deployed commercially, we can eliminate an animal welfare issue while maintaining a quality product for consumers.”

Intact male pigs experience “boar taint,” which causes an unpleasant odor and unsavory taste in the resulting meat. Male pigs are castrated young to prevent boar taint; however pain relievers are not always administered. Castrated piglets can show an acute physiological stress response to castration, including increased stress hormone levels, elevated heart rate and demonstrated indicators of pain that can last for four days following the procedure. The European Union has banned the practice of swine castration, but its implementation has been delayed amid challenges to the costs of implementation.  

This project has successfully deleted the gene that triggers the release of hormones necessary for sexual maturation in the piglets’ DNA, preventing them from reaching puberty, and thus negating the need to castrate the pigs. The next step in this research is determining the commercial viability of castration-free pigs. Since these prototype pigs were created to be permanently prepubescent, the alliance is determining how to breed these pigs without comprising traits like feed efficiency and meat quality. The alliance comprises some of the largest pig genetic companies in the world, possessing the capacity and capabilities needed to supply these permanently prepubescent pigs to pork producers worldwide.

Research is being led by Principal Investigator Tad Sonstegard, chief executive and scientific officer of Acceligen, Recombinetics’ agriculture division.

“The birth of these castration-free prototype piglets using commercially relevant genetics is just another example of how Acceligen is working to deploy our breeding technologies to help producers better meet the demands of consumers and producers to improve food animal well-being,” says Sonstegard. “The technical expertise and support provided by Hyphor and the Foundation for Food and Agriculture Research gives our alliance the capability to meet these demands with the highest standards. Together we will bring the castration-free trait to market and provide solutions to benefit the pork industry,” says Sonstegard.

“At Hendrix Genetics, we are very excited about the birth of the first castration-free piglets. This is an important step to end one of the biggest concerns of the swine industry regarding animal well-being. Within Hypor, Hendrix Genetics’ swine business unit, we are continuously exploring new opportunities to support the pork value chain with innovative and sustainable genetic solutions,” says Luis Prieto Garcia, managing director of Swine, Hendrix Genetics.

Source: Foundation for Food and Agriculture Research, which is solely responsible for the information provided, and wholly owns the information. Informa Business Media and all its subsidiaries are not responsible for any of the content contained in this information asset.
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